Abstract

Review Article

Neurobiology of Common Sleep Disorders

Zhao Liu*, Abdullah Tolaymat and Sreenivas K Avula

Published: 14 August, 2018 | Volume 2 - Issue 2 | Pages: 039-046

Sleep disorders in human are common and detrimental to general health of all age groups. While the neurobiological mechanisms of sleep disorders are not yet fully understood, recent advances in research on the sleep-wake regulation mechanism, genetic and epigenetic factors, cognitive, emotional and physiological changes related to sleep have shed light on the mechanistic basis of sleep disorders. Over the past two decades, studies in Drosophila have yielded new insights into basic questions regarding sleep function and regulation. More recently, powerful genetic approaches in the fly have been applied toward studying primary human sleep disorders and other disorders associated with dysregulated sleep. In this review, we discussed recent advances in neurobiology of sleep-wave cycle and common sleep disorders. Understanding these mechanisms are important in the diagnosis, treatment and prevention of these common disorders.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001013 Cite this Article Read Full Article PDF

Keywords:

Sleep disorder; Insomnia; Hypersomnia; Parasomnia; Circadian Rhythms; Sleep-related movement disorders; Narcolepsy; Circadian rhythm disorder; Drosophilae; Fruit fly; Circadian gene period

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