Abstract

Review Article

Brain washing systems and other circulating factors in some neurological condition like Parkinson (Pd) and vascular and diabetic dementia: How dynamics- saturation of clearance can act on toxic molecule?

Mauro Luisetto*, Farhan Ahmad Khan, Akram Muhamad, Ghulam Rasool Mashori, Behzad Nili Ahmadabadi and Oleg Yurevich Latiyshev

Published: 24 January, 2020 | Volume 4 - Issue 1 | Pages: 001-013

Observing the epidemiology of some neurodegenerative disease is interesting to verify some similarity and also related advanced or non-advanced countries and related diet habits. There are relationship between this conditions and diet habits? Some neurological condition related neuro-degeneration can be related to a complex dynamic system like the glymphatic system and the brain vascular clearance. Failure in this system seem related to aggravates of some condition like PD or vascular or diabetic dementia. (Animal model). But what happen if this dynamic system is saturated? A deep investigation related the specific role in CNS make possible to search new innovative strategies. The social economic cost for the neurodegenerative disease is the right tool to new research.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001028 Cite this Article Read Full Article PDF

Keywords:

Brain glymphatic system; Brain washing system; Vascular dementia; PD; DA; Diabetic dementia; New therapeutic strategy; Toxicology approach; Clearance of wasting molecule; Kinetics; Saturation; Genetic; Depurative approach

References

  1. Wenyan Z, Tinglin P, Weixi F, Ming L, Ying Z, et al. Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein. Translational Neurodegeneration. 2019; 8: 7. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30867902
  2. Abdelrahman YF, Susan CF, Adviye E. Brain Vasculature and Cognition Renin-Angiotensin System, Endothelin and Beyond.
  3. Ranjini KS, Chinnaswamy K, Stanley S, Pazhani S. Novel Detox Gel Depot sequesters β-Amyloid Peptides in a mouse model of Alzheimer’s disease. Int J Pept Res Ther. 2012; 18: 99-106. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22712003
  4. Dong SK, Ho-Il Choi, Yun W, Yu L, Barry J. et al. A New Treatment Strategy for Parkinson's disease through the Gut–Brain Axis the Glucagon-Like Peptide-1 Receptor Pathway. Cell Transplant. 2017 Sep; 26(9): 1560-1571. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29113464
  5. Ling W, Qi Z, Huanbin L, Hong Z. SPECT Molecular Imaging in Parkinson's Disease. J Biomed Biotechnol. 2012; 2012: 412486. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22529704
  6. Jiang W, Ju C, Jiang H, Zhang D. Dairy foods intake and risk of Parkinson's disease: a dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol. 2014; 29: 613-619. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24894826
  7. Stacey ES, Jose AS, Hope B, Judith AP. The emerging role of nutrition in Parkinson's disease. Front Aging Neurosci. 2014; 6: 36. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24639650
  8. Anderson C, Checkoway H, Franklin GM, Beresford S, Smith-Weller T, et al. Dietary factors in Parkinson's disease: the role of food groups and specific foods. Mov Disord. 1999; 14: 21-27. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/9918340
  9. Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med. 2012; 4: 147ra111. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22896675
  10. Hedok L, Lulu X, Mei Y, Hongyi K, Tian F, et al. The Effect of Body Posture on Brain Glymphatic Transport. J Neurosci. 2015; 35: 11034-11044. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26245965
  11. Maiken N. Garbage Truck of the Brain. Science. 2013; 340: 1529-1530. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23812703
  12. Lee HJ, Khoshaghideh F, Patel S, Lee SJ. Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway. J Neurosci. 2004; 24: 1888-1896. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/14985429
  13. Marques O, Outeiro TF. Alpha-synuclein: from secretion to dysfunction and death. Cell Death & Disease. 2012; 3.
  14. Bao LS, Li-hua W, Tuo Y, Jing-yi S, Lei-lei M, et al. Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases. Prog Neurobiol. 2018; 118: 163-164. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28903061
  15. Iliff JJ, Chen MJ, Plog BA, Zeppenfeld DM, Soltero M, et al. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J Neurosci. 2014; 34: 16180-16193. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25471560
  16. Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018; 17: 1016-1024.
  17. Luisetto M, Ibrahim G, Muhamad A, Areeba I, Behzad N. Brain Washing System-The System by Which the Wasting Molecules are removed from Brain. J Anat Pathol. 2019; 1: 1-5.
  18. Luisetto M, Naseer A, Behzad N, Gamal AH, Ghulam RM, et al. Endogenus Toxicology: Modern Physio- Pathological Aspects and Relationship with New Therapeutic Strategies. An Integrative Discipline Incorporating Concepts from Different Research Discipline like Biochemistry, Pharmacology and Toxicology. Arch Cancer Sci Ther. 2019; 3: 001-024.
  19. Bryan AK, Viviane L. Vertebrate food products as a potential source of prion-like α-synuclein. Parkinson’s disease. 2017; 3: 33. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/29184902

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