Abstract

Research Article

Comorbidity of alcohol dependence with attention-deficit/hyperactivity disorder and the role of executive dysfunctions

Caterina Pistarini*, Gloria Tosi, Giovanni Vittadini, Ines Giorgi, Elena Fiabane and Paola Palladino

Published: 30 January, 2018 | Volume 2 - Issue 1 | Pages: 001-010

Background: This study aims to retrospectively investigate the comorbidity of ADHD multiple symptoms (behavioral) with alcohol addiction in a sample of adult alcohol-dependent patients and to test their current attentional skills (behavioral and cognitive).

Methods: Thirty-two adult alcohol-dependent patients were examined for ADHD using a semi-structured interview and the Mini Mental State Examination to evaluate attention and inhibition functions. Brown ADD Scales were used to specifically examine ADHD syndrome. Patients were compared with thirty matched control participants selected from healthy population in few measures of attentional control and working memory.

Results: 50% of patients showed evidence of primary ADHD symptoms: specifically, 28.12% showed criteria for ADHD highly probable, 12.50% for ADHD probable but not certain and 9.38% for ADHD possible but not likely. Patients also revealed several deficits in the selective visual attention, interference control and verbal working memory compared to the control group.

Conclusions: These results revealed that adult alcohol-dependent patients had retrospectively high comorbidity with ADHD and significant current deficits of the executive functions. These findings suggest the importance of early diagnosis and treatment of ADHD in order to prevent the development of alcohol dependence.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001008 Cite this Article Read Full Article PDF

Keywords:

Alcohol dependence; ADHD; Executive function

References

  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed (DSM-IV). Washington, DC. 1994.
  2. Adler L, Cohen J. Diagnosis and evaluation of adults with ADHD. Psychiatr Clin North Am. 2004; 27: 187-201. Ref.: https://goo.gl/g5xzde
  3. Biederman J, Faraone Stephen V, Wilens TE. Attention-Deficit Hyperactivity Disorder in Adults. Am Med Association. 2004; 292: 619-623. Ref.: https://goo.gl/VjLSTK
  4. Cuffe SP, Visser SN, Holbrook JR, Danielson ML, Geryk LL, et al. ADHD and psychiatric comorbidity: functional outcomes in a school-based sample of children. J Atten Disord. 2015; 25: 1087054715613437. Ref.: https://goo.gl/4PZX6X
  5. Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, et al. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry. 2006; 163: 716-723. Ref.: https://goo.gl/HkxvTf
  6. Biederman J, Wilens TE, Mick E, Milberger S, Spencer TJ, et al. Psychoactive substance use disorders in adults with attention deficit hyperactivity disorder (ADHD): effects of ADHD and psychiatric comorbidity. Am J Psychiatry. 1995; 152: 1652-1658. Ref.: https://goo.gl/RHNiaE
  7. Biederman J, Faraone SV. Attention-deficit hyperactivity disorder. Lancet. 2005; 366: 237-248. Ref.: https://goo.gl/HcagmL
  8. Kessler RC, Chiu WT, Demler O, Walters EE, Merikangas KR. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry. 2005; 62: 617-627. Ref.: https://goo.gl/7rciFs
  9. Daurio AM, Aston SA, Schwandt ML, Bukhari MO, Bouhlal S, et al. Impulsive personality traits mediate the relationship between adult attention deficit hyperactivity symptoms and alcohol dependence severity. Alcohol Clin Exp Res. 2017; 42: 173-183. Ref.: https://goo.gl/hhYV4B
  10. Lee SS, Humphreys KL, Flory K, Liu R, Glass K. Prospective association of childhood attention-deficit/hyperactivity disorder (ADHD) and substance use and abuse/dependence: A meta-analytic review. Clin Psychol Rev. 2011; 31: 328-341. Ref.: https://goo.gl/CNdsmz
  11. Kim D, Lee D, Lee J, Namkoong K, Jung YC. Association between childhood and adult attention deficit hyperactivity disorder symptoms in Korean young adults with Internet addiction. J Behav Addict. 2017; 6: 345-353. Ref.: https://goo.gl/cm1dFz
  12. Wilens TE. Attention-deficit/hyperactivity disorder and the substance use disorders: the nature of the relationship, subtypes at risk, and treatment issues. Psychiatr Clin North Am. 2004; 27: 283-301. Ref.: https://goo.gl/HTdKoh
  13. Ohlmeier MD, Peters K, Te Wildt BT, Zedler M, Ziegenbein M, et al. Comorbidity of Alcohol and Substance Dependence with Attention-Deficit/Hyperactivity Disorder (ADHD). Alcohol Alcohol. 2008; 43: 300-304. Ref.: https://goo.gl/p8W4k3
  14. Biederman J, Faraone SV, Spencer TJ, Mick E, Monuteaux MC, et al. Functional Impairments in adults with self-reports of diagnosed ADHD: a controlled study of 1001 adults in the community. J Clin Psychiatry. 2006; 67: 524-540. Ref.: https://goo.gl/m6bMro
  15. Seidman LJ, Valera EM, Makris N. Structural brain imaging of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005; 57: 1263-1272. Ref.: https://goo.gl/h5wUxc
  16. Seidman LJ, Valera E, Bush G. Brain function and structure in adults with attention-deficit/hyperactivity disorder. Psychiatr Clin North Am. 2004; 27: 323-347. Ref.: https://goo.gl/M2Dm7i
  17. Alderson RM, Kasper LJ, Hudec KL, Patros CH. Attention-deficit/hyperactivity disorder (ADHD) and working memory in adults: a meta-analytic review. Neuropsychology. 2013; 27: 287-302. Ref.: https://goo.gl/8oajDg
  18. Lynskey MT, Hall W. Attention Deficit Hyperactivity Disorder and substance use disorders: is there a causal link? Addiction. 2001; 96: 815-822. Ref.: https://goo.gl/Nju5RP
  19. Del Corno F, Lang M, Schadee H. Brown ADD Scales Taratura Italiana, Firenze: Giunti OS. 2010.
  20. Palladino P. The role of interference control in working memory: a study with children at risk of ADHD. Q J Exp Psychol. 2006; 59: 2047-2055. Ref.: https://goo.gl/pvFqwZ
  21. Palladino P, Ferrari M. Interference control in working memory: Comparing groups of children with atypical development. Child Neuropsychol. 2013; 19: 37-54. Ref.: https://goo.gl/U9rsSt
  22. Hurks PP, Jolles J, Krabbendam L, Marchetta ND. Interference control, working memory, concept shifting, and verbal fluency in adults with attention-deficit/hyperactivity disorder (ADHD). Neuropsychology. 2008; 22: 74-84. Ref.: https://goo.gl/UgRZxX
  23. Willcutt EG, Doyle AE, Nigg JT, Faraone SV, Pennington BF. Validity of the executive function theory of Attention-Deficit/Hyperactivity Disorder: A meta-analytic review. Biol Psychiatry. 2005; 57: 1336-1346. Ref.: https://goo.gl/UYTn7B
  24. Wilens TE, Martelon M, Joshi G, Bateman C, Fried R, et al. Does ADHD predict Substance-Use Disorders? A 10-year follow up study of young adults with ADHD. J Am Acad Child Adolesc Psychiatry. 2011; 50: 543-553. Ref.: https://goo.gl/hcrn2y
  25. Ohlmeier MD, Peters K, Kordon A, Seifert J, Wildt BT, et al. Nicotine and alcohol dependence in patients with comorbid attention-deficit/hyperactivity disorder (ADHD). Alcohol Alcohol. 2007; 42: 539-543. Ref.: https://goo.gl/zdN4nJ
  26. Woods SP, Lovejoy DW, Ball JD. Neuropsychological characteristics of adults with ADHD: A comprehensive review of initial studies. Clin Neuropsychol. 2002; 16: 12-34. Ref.: https://goo.gl/2UFXbQ
  27. Carretti B, Cornoldi C, De Beni R, Palladino P. What happens to information to be suppressed in working memory tasks? Short and long term effects. Q J Exp Psychol. 2004; 57: 1059-1084. Ref.: https://goo.gl/1nYfPk
  28. Re A, De Franchis V, Cornoldi C. Working memory control deficit in kindergarten ADHD children. Child Neuropsychol. 2010; 16: 134-144. Ref.: https://goo.gl/G4wLRQ
  29. Van Der Elst W, Van Boxtel MP, Van Breukelen GJ, Jolles J. The Concept Shifting Test: Adult normative data. Psychol Assess. 2006; 18: 424-432. Ref.: https://goo.gl/eriy5n
  30. Volkow ND, Wang GJ, Newcorn JH, Kollins SH, Wigal TL, et al. Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. Mol Psychiatry. 2011; 16: 1147-1154. Ref.: https://goo.gl/jxRwys
  31. Carpentier PJ, De Jong AJ, Dijkstra AG, Verbrugge AG, Krabbe FM. A controlled trial of methylphenidate in adults with attention deficit/hyperactivity disorder and substance use disorders. Addiction. 2005; 100: 1868-1874. Ref.: https://goo.gl/9f79pH
  32. Biederman J. Impact of Comorbidity in Adults with Attention-Deficit Hyperactivity Disorder. J Clin Psychiatry. 2004; 65: 3-7. Ref.: https://goo.gl/sYTqhe
  33. Knutson CK, O’Malley M. Adult attention-deficit/hyperactivity disorder: A survey of diagnosis and treatment practices. J Am Acad Nurse Pratictioners. 2010; 22: 593-601. Ref.: https://goo.gl/eJ42Vd

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