Abstract

Mini Review

Spinal muscular atrophy counteracted by Agrin biological NT-1654

Jes Paul*

Published: 20 April, 2018 | Volume 2 - Issue 1 | Pages: 011-013

Spinal muscular atrophy (SMA) is a genetic and gravely disease, portrayed by motor neuron (MN) death, thereby leading to progressive and accelerating muscle fragility, respiratory collapse, and, in the most severe cases, it even pave the way to death. At the neuromuscular junction (NMJ), abnormally have been reported in SMA, including neurofilament (NF) aggregation at presynaptic terminals, immature and smaller endplates, lowered transmitter release, and, eventually, muscle denervation. In this review the role of Agrin in SMA is studied. This review highlights the antagonizing role of Agrin in SMA

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001009 Cite this Article Read Full Article PDF

Keywords:

Motor neuron disease; Neuromuscular junctions; Muscle; Motor performance; Innervation

References

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