Abstract

Research Article

Brain and immune system: KURU disease a toxicological process?

Luisetto M*, Behzad Nili-Ahmadabadi, Ghulam Rasool Mashori, Ahmed Yesvi, Ram Kumar Sahu, Heba Nasser, Cabianca luca and Farhan Ahmad Khan

Published: 03 May, 2018 | Volume 2 - Issue 1 | Pages: 014-027

Starting from observation of pathogenesis of KURU disease we try to investigate the immunologic role played by central nervous systems. A deeply knowledge in the transmission model of this pathology can be an imaging/diagnostic tool to Verify the progression of this prion molecule from gastro intestinal systems to the brain. (After cannibalistic behavior). The prions can be considered a sort of trace ant in KURU to monitoring this process and immune- brain relationship. Interesting information can be obtained useful to produce new pharmacological strategies in some other degenerative brain disease involving innate immune system activation.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001010 Cite this Article Read Full Article PDF

Keywords:

Prion disease pathogenesis; Transmissible spongiform encephalopathy; Innate immune system brain disease; Neurodegenerative disease

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