Abstract

Mini Review

Considering antioxidant supplements as a means to prevent diseases

Fukka You, Yoshiaki Harakawa and Haruhiko Inufusa*

Published: 27 April, 2023 | Volume 7 - Issue 1 | Pages: 014-016

Oxidative stress has been implicated in Alzheimer’s and many other diseases and more recently, it has been linked to various COVID-19-related symptoms. Many diseases do not develop immediately as a result of the accumulated causes or injury, but rather, as a result of prolonged exposure to elevated oxidative stress, which disrupts the body’s natural homeostatic functions.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001075 Cite this Article Read Full Article PDF

Keywords:

Oxidative stress; Antioxidant; Twendee X; Alzheimer’s disease (AD); COVID-19

References

  1. Tadokoro K, Ohta Y, Inufusa H, Loon AFN, Abe K. Prevention of Cognitive Decline in Alzheimer's Disease by Novel Antioxidative Supplements. Int J Mol Sci. 2020 Mar 13;21(6):1974. doi: 10.3390/ijms21061974. PMID: 32183152; PMCID: PMC7139972.
  2. Praticò D, Clark CM, Liun F, Rokach J, Lee VY, Trojanowski JQ. Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease. Arch Neurol. 2002 Jun;59(6):972-6. doi: 10.1001/archneur.59.6.972. Erratum in: Arch Neurol 2002 Sep;59(9):1475. PMID: 12056933.
  3. Cecchini R, Cecchini AL. SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression. Med Hypotheses. 2020 Oct;143:110102. doi: 10.1016/j.mehy.2020.110102. Epub 2020 Jul 13. PMID: 32721799; PMCID: PMC7357498.
  4. Ndeupen S, Qin Z, Jacobsen S, Bouteau A, Estanbouli H, Igyártó BZ. The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory. iScience. 2021 Dec 17;24(12):103479. doi: 10.1016/j.isci.2021.103479. Epub 2021 Nov 20. PMID: 34841223; PMCID: PMC8604799.
  5. Haruhiko I. Composition for protection against cytotoxic effects. Tima Foundation. Patent No. 5777821. 2015-9-9.
  6. Inufusa H. Characterization of cell protection effects of Twendee X by oxidative stress. J World Mitochondria Soc. 2016; 2: 42.
  7. Liu X, Yamashita T, Shang J, Shi X, Morihara R, Huang Y, Sato K, Takemoto M, Hishikawa N, Ohta Y, Abe K. Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion. J Stroke Cerebrovasc Dis. 2019 Jul;28(7):1993-2002. doi: 10.1016/j.jstrokecerebrovasdis.2019.03.029. Epub 2019 Apr 24. PMID: 31029568.
  8. Kusaki M, Ohta Y, Inufusa H, Yamashita T, Morihara R, Nakano Y, Liu X, Shang J, Tian F, Fukui Y, Sato K, Takemoto M, Hishikawa N, Abe K. Neuroprotective Effects of a Novel Antioxidant Mixture Twendee X in Mouse Stroke Model. J Stroke Cerebrovasc Dis. 2017 Jun;26(6):1191-1196. doi: 10.1016/j.jstrokecerebrovasdis.2017.01.003. Epub 2017 Feb 9. PMID: 28190603.
  9. Tadokoro K, Morihara R, Ohta Y, Hishikawa N, Kawano S, Sasaki R, Matsumoto N, Nomura E, Nakano Y, Takahashi Y, Takemoto M, Yamashita T, Ueno S, Wakutani Y, Takao Y, Morimoto N, Kutoku Y, Sunada Y, Taomoto K, Manabe Y, Deguchi K, Higashi Y, Inufusa H, You F, Yoshikawa T, von Greiffenclau MM, Abe K. Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study. J Alzheimers Dis. 2019;71(3):1063-1069. doi: 10.3233/JAD-190644. PMID: 31476161. 
  10. You F, Tanaka S, Inufusa H. Effects of Antioxidant composition Twendee X on side effects of SARS-CoV-2 mRNA vaccine. Brain Supplement. 2022; 4: 1-6.
  11. You F, Tanaka S, Inufusa H. Antioxidant composition Twendee X may improve long COVID symptoms. Brain Supplement. 2022; 4: 7-12.

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?