Abstract

Research Article

Experimental ‘hindbrain related’ syringomyelia: some mechanisms of spinal cord damage

Sergey N Larionov*, Sorokovikov VA and Rudakova AV

Published: 06 October, 2017 | Volume 1 - Issue 1 | Pages: 033-038

Syringomyelia in combination with inherent or acquired hindbrain abnormalities is the non seldom and at the same time controversial issue.

Purpose: The etiology and pathogenesis creates a lot of discussion.

Methods: Experimental syringomyelia was induced in 20 anesthetized rabbits by injecting 0.5 ml of 25% kaolin suspension into the cisterna magna. Six rabbits with puncture and injection sterile saline NaCl were used as a control. The animals were sacrificed 1, 2, 4 and 6 months after the kaolin injection. Four hydrocephalus rabbits were sacrificed in 17 hours after the puncture of lateral ventricle with injection of solution of colloidal gold labeled human albuminum. The sections of the brain and spinal cord were stained with hematoxylin and eosin by Nissle and Marchi methods and with immunogold technique. Retropharyngeal lymph nodes of the animals were examined by electron microscopy.

Conclusion: Our observation showed that water hammer effect and internal destruction of the spinal cord may lead to continuous antigen stimulation of regional lymph nodes and play an important role in pathogenesis of experimental syringomyelia.

Read Full Article HTML DOI: 10.29328/journal.jnnd.1001006 Cite this Article Read Full Article PDF

References

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  2. Williams B. Simultaneous cerebral and spinal fluid pressure recordings. Cerebrospinal dissociation with lesions at the foramen magnum. Acta Neurochir. 1981; 59: 123-142. Ref.: https://goo.gl/9W2xbr
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  7. Weller RO, Djunda E, Yow HY, Carare RO. Lymphatic drainage of the brai and pathophysiology of neurological disease. Acta Neuropathol. 2009; 117: 1-14. Ref.: https://goo.gl/oZ7XRp

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