Protective functions of AEURA in Cell Based Model of Stroke and Alzheimer disease

Main Article Content

Jigar Modi
Ahmed Altamimi
Ashleigh Morrell
Hongyuan Chou
Janet Menzie
Andrew Weiss
Michael L Marshall
Andrew Li
Howard Prentice
Jang-Yen Wu

Abstract

Stroke and neurodegenerative diseases including Alzheimer’s disease (AD) are responsible for a major proportion of mortalities in the elderly. We have previously investigated novel mechanism-based therapies of AEURA in cell culture models against viral infection and in glutamate excitotoxity. In our new studies, we propose that the homeopathic formula AEURA could serve as a potential therapeutic agent for stroke & for AD. In examining AEURA treatment of PC12 cells exposed to glutamate excitotoxicity, hypoxia /re-oxygenation injury and A-Beta toxicity. We demonstrated an increased survival rate in AEURA treated cells by comparison to control cells. In examining the therapeutic potential of AEURA in PC12 cells this homeopathic agent was found to be neuroprotective against either glutamate induced toxicity, hypoxia /re-oxygenation stress or cell stress resulting from viral infection (with either HSV-1 or rhinovirus). Our ongoing studies involve examining the neuroprotective potential AEURA in vivo using rodent models of stroke & AD.

Article Details

Modi, J., Altamimi, A., Morrell, A., Chou, H., Menzie, J., Weiss, A., … Wu, J.-Y. (2017). Protective functions of AEURA in Cell Based Model of Stroke and Alzheimer disease. Journal of Neuroscience and Neurological Disorders, 1(1), 016–023. https://doi.org/10.29328/journal.jnnd.1001003
Research Articles

Copyright (c) 2017 Modi J, et al.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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