The turing machine theory for some spinal cord and brain condition, A toxicological - antidotic depurative approach
Article Sidebar
Main Article Content
Abstract
Aim of this work is to produce a general theory related an new depurative strategy to be devalued for reduce or delay some spinal cord and brain degenerative and inflammatory chronic disease or acute traumatic condition. It is used and informatics approach in order to set correct the problem and the process. Scope of this project is to submit to the researcher a new therapeutic strategy (under a depurative- toxicological-pharmacological) in this complex kind of disease. A Turing machine theory say us a method to TRASLATE the need of a strategy in a practical hypotesys of work. A global conceptual map can help in this field.
Article Details
Copyright (c) 2019 Luisetto M, et al.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Mauro L, Behzad NA, Nilesh MM, Ghulam RM, Ram KS, et al. Amyotrophic Lateral Sclerosis and Endogenous-Esogenous Toxicological Movens: New Model to Verify Other Pharmacological Strategies. J of Pharmacol & Clin Res. 2018; 6: 555690.
Luisetto M, Almukhtar N, Rafa AY, Ahmadabadi BN, Mashori GR, et al. Role of plants, environmental toxins and physical neurotoxicological factors in Amyotrophic lateral sclerosis, AD and other Neuro-degenerative Diseases.
Luisetto M, Almukhtar N, Ahmadabadi BN, Hamid GA, Mashori GR, et al. Clinical Pathology & Research Journal Endogenus Toxicology: Modern Physio- Pathological Aspects and Relationship with New Therapeutic Strategies. An Integrative Discipline Incorporating Concepts from different Research Discipline like Biochemistry, Pharmacology and Toxicology. Clin Pathol.
Alabdali A, Al-Ayadhi L, El-Ansary A. A key role for an impaired detoxification mechanism in the etiology and severity of autism spectrum disorders. Behav Brain Funct. 2014; 10: 14. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24776096
Nedergaard M, Steven A. Brain Drain Goldman Sci Am. 2016; 314: 44–49.
Dringen R, Pawlowski PG, Hirrlinger J. Peroxide detoxification by brain cells. J Neurosci Res. 2005; 79: 157-165.
Lee H, XieL, Yu M, Kang H, Feng T, et al. The Effect of Body Posture on Brain Glymphatic Transport. J Neurosci. 2015; 35: 11034–11044. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26245965
Xu J, Huang G, Zhang K, Sun F, Xu T, et al. Activation in Astrocytes Contributes to Spinal Cord Ischemic Tolerance Induced by Hyperbaric Oxygen Preconditioning. J Neurotrauma. 2014; 31: 1343–1353. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24716787
Hodges GR, Watanabe I. Chemical injury of the spinal cord of the rabbit after intracisternal injection of gentamicin: an ultrastructural study. J Neuropathol Exp Neurol. 1980; 39: 452-75. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/6894308
Sundaram RK, Kasinathan C, Stein S, Sundaram P. Detoxification depot for beta-amyloid peptides. Curr Alzheimer Res. 2008; 5: 26-32. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/18288928
Marsala M, Malmberg AB, Yaksh TL. The spinal loop dialysis catheter: characterization of use in the unanesthetized rat. J Neurosci Methods. 1995; 62: 43-53. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8750084
Hong Y, Palaksha KJ, Park K, Park S, Kim HD, et al. Melatonin plus exercise-based neurorehabilitative therapy for spinal cord injury. J. Pineal Res. 2010; 49: 201–209. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20626592
Rathore KI, Kerr BJ, Redensek A, López-Vales R, Jeong SY, et al. Ceruloplasmin protects injured spinal cord from iron-mediated oxidative damage. J Neurosci. 2008; 28: 12736 –12747. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19036966
Rajiv R. Ratan, Mark Noble. Novel multi-modal strategies to promote brain and spinal cord injury recovery. Stroke. 2009; 40: S130–S132. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19064774
Goetz T, Romero-Sierra C, Ethier R, Henriksen RN. Modeling of therapeutic dialysis of cerebrospinal fluid by epidural cooling in spinal cord injuries. Journal of Neurotrauma. 1988; 5: 139-150. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/3225857
Freund P, Curt A, Friston K, Thompson A. Tracking Changes following Spinal Cord Injury: Insights from Neuroimaging. Neuroscientist. 2013; 19: 116–128. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22730072
Raisman G. A promising therapeutic approach to spinal cord repair. J R Soc Med. 2003; 96: 0141-0768. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12782687
Camandola S, Mattson MP. Brain metabolism in health, aging, and neuro-degeneration. BMC Neurol. 2017; 36: 1474-1492. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27875990
Farron L.McIntee, PatriziaGiannoni, StevenBlais, GeorgeSommer, Thomas A Neubert, et al. Invivo Differential Brain Clearance and Catabolism of Monomeric and Oligomeric Alzheimer’s Abprotein.
Walker S. Jackson. Review Selective vulnerability to neuro-degenerative disease: the curious case of Prion Protein. Disease Models & Mechanisms. 2014; 7: 21-29.
Marsala M, Sorkin LS, Yaksh TL. Transient Spinal Ischemia in Rat: Characterization of Spinal Cord Blood Flow, Extracellular Amino Acid Release, and Concurrent Histopathological Damage. J Cereb Blood Flow Metab. 1994; 14: 604-614. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8014207
Sakkaa L, Coll G, Chazala J. Anatomy and physiology of cerebro-spinal fluid. Eur Ann Otorhinolaryngol Head Neck Dis. 2011; 128: 309-316. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22100360
Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, et al. Clearance systems in the brain-implications for Alzheimer disease. Nat Rev Neurol. 2015; 11: 457-470. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26195256
Thompson SJ, Bernards CM. Barrier Properties of the Spinal Meninges Are Markedly Decreased by Freezing Meningeal Tissues.
Weller J, Budson A. Current understanding of Alzheimer’s disease diagnosis and treatment. 2018.
Nalivaeva NN, Turner AJ. Targeting amyloid clearance in Alzheimer’s disease as a therapeutic strategy. Br J Pharmacol. 2019. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30710367
Ahmad MH, Fatima M, Mondal AC. Influence of microglia and astrocyte activation in the neuroinflammatory pathogenesis of Alzheimer’s disease: Rational insights for the therapeutic approaches. J Clin Neurosci. 2019. 59: 6-11. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30385170
Malik GA, Roberts NP. Treatments in Alzheimer’s disease. J Neurol. 2017; 264: 416–418.
Thelin EP, Nelson DE, Ghatan PH, Bellander BM. Microdialysis monitoring of CSF parameters in severe traumatic brain injury patients: a novel approach. Frontiers in neurology. 2014. 5: 159. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25228896
Ågren-Wilsson A, Roslin M, Eklund A, Koskinen L, Bergenheim A, et al. Intracerebral microdialysis and CSF hydrodynamics in idiopathic adult hydrocephalus syndrome. J Neurol Neurosurg Psychiatry. 2003; 74: 217–221. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/12531954
Shulyakov AV, Benour M, Del Bigio MR. Surface dialysis after experimental brain injury: modification of edema fluid flow in the rat model Laboratory investigation. 2008; 109.
Mayer F, Mayer N, Chinn L, Pinsonneault RL, Kroetz D, et al. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. J Neurosci. 2009; 29: 3538–3550. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19295159
Bueno D, Garcia-Fernàndez J. Evolutionary development of embryonic cerebrospinal fluid composition and regulation: an open research field with implications for brain development and function. Fluids and Barriers of the CNS. 2016; 13: 5. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26979569
Park M, Moon WJ. Structural MR Imaging in the Diagnosis of Alzheimer’s disease and Other Neurodegenerative Dementia: Current Imaging Approach and Future Perspectives. J Radiol. 2016; 17: 827-845. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27833399
Sundaram RK, Kasinathan C, Stein S, Sundaram P. Novel Detox Gel Depot sequesters β-Amyloid Peptides in a mouse model of Alzheimer’s disease. Int J Pept Res Ther. 2012; 18: 99-106.