Tamsulosin and Dementia in old age: Is there any relationship?

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Submitted: August 28, 2019
Published: Oct 1, 2019
DOI: 10.29328/journal.jnnd.1001025
Keywords:
Benign prostatic hyperplasia, Prostatic hyperplasia, Cognitive functions, Tamsulosin, Dementia, Adrenergic alpha-1 receptor antagonists

Main Article Content

Rebecca Renata Lapenda do Monte
Undergraduate Student of Medicine, UnP-Potiguar University, Laureate International Universities, Natal, Brazil
Karina de Andrade Vidal Costa
Undergraduate Student of Medicine, UnP-Potiguar University, Laureate International Universities, Natal, Brazil
Arnaldo Santiago Nunes Junior
Urologist and Professor, Potiguar University, UnP-Laureate International Universities, Natal, Brazil
Amália Cinthia Meneses Rêgo
Postgraduate Program, Biotechnology, Potiguar University, UnP-Laureate International Universities, Natal, Brazil
Irami Araújo-Filho
Full Professor, Department of Surgery, Federal University of Rio Grande do Norte, Postgraduate Program, Biotechnology, Potiguar University, UnP-Laureate International Universities, Natal, Brazil

Abstract

Tamsulosin is used to treat Benign Prostatic Hyperplasia (BPH), prescribed annually to about 12.6 million patients worldwide. It is an alpha-adrenergic antagonist that reduces the tone of the prostate smooth muscle involved in the pathophysiology of BPH. By acting on alpha 1A receptors, predominant in the prostate, tamsulosin also acts on receptors present in the brain. This study consisted of a literature review aimed at disseminating scientific knowledge about the relationship between the use of tamsulosin and the onset of dementia. PubMed, Scopus, Scielo, Embase, and Web of Science studies involving dementia in patients using tamsulosin in the last five years were selected. The review showed a risk correlation and a higher incidence of dementia in treated patients. The risk ratio, when compared to other medicines, approached 1.20. In conclusion, it was identified the need for clinical trials with higher sampling power to increase relational significance due to the high prevalence of BPH and the extensive use of tamsulosin in elderly patients with the disease.

Article Details

do Monte, R. R. L., Vidal Costa, K. de A., Junior, A. S. N., Meneses Rêgo, A. C., & Araújo-Filho, I. (2019). Tamsulosin and Dementia in old age: Is there any relationship?. Journal of Neuroscience and Neurological Disorders, 3(2), 145–147. https://doi.org/10.29328/journal.jnnd.1001025
Research Articles

Copyright (c) 2019 do Monte RRL, et al.

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