Association of EIF4G1 Gene Variants with Sporadic Parkinson’s disease in a Chinese Han Population
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Abstract
Eukaryotic translation initiation factor 4G1 (eIF4G1) has been implicated in Parkinson’s disease (PD) pathogenesis. However, the contribution of EIF4G1 genetic variation to PD susceptibility remains unclear. To investigate the association between the EIF4G1 variant rs2178403 and PD risk. We analyzed EIF4G1 expression in PD and control samples using public GEO datasets (GSE54536). Additionally, we conducted a hospital-based case-control study with 541 sporadic PD patients and 401 age-/sex-matched healthy controls of Han Chinese ancestry. Genotyping of rs2178403 was performed using Sequenom MassARRAY iPLEX. GEO data revealed a non-significant trend toward elevated EIF4G1 expression in PD samples (p < 0.1). Genetic analysis identified a significant association between the rs2178403 GG genotype and increased PD risk under a recessive model (OR = 1.31, 95% CI = 1.010–1.703, p = 0.042). Stratified analysis showed a stronger effect in females. These findings suggest rs2178403 may contribute to PD susceptibility in the Han Chinese population. This study supports an association between the EIF4G1 variant rs2178403 and PD risk. Further investigation into EIF4G1 inhibition as a potential therapeutic strategy for PD is warranted.
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